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Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis

In the Purkinje cell layer, the mean number of dark neurons significantly increased in the CN group (2.465 0.135/10 m 2 ) in comparison with the VC group (P = 0.0049, Figures 4C, D, I)

NavotDBerghPAWilliamsMAGarrisiGJGuzmanISandlerBet al

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

As noted above, NADPH is required for reductive detoxification and fatty acid synthesis

This interference disrupts the intracellular redox equilibrium, thereby disturbing the efficiency and progression of the ubiquitination cascade