glutathione in u87mg cells The effect of polysaccharides from Cibotium barometz on enhancing temozolomide–induced exhausted human glioblastoma U87 cells, as revealed by 1H NMR metabolomics analysis Glutathione depletion sensitizes cisplatin- and

Description

and A.S analyzed data

Abbreviations ACD: Accidental cell death RCD: Regulated cell death ROS: Reactive oxygen species GSH: Glutathione GPX4: Glutathione peroxidase 4 PTGS2: Prostaglandin-endoperoxide synthase 2 FSP1: Ferroptosis suppressor protein 1 NRF2: Nuclear factor erythroid 2-related factor2 RIPK1: Recombinant receptor-interacting serine threonine kinase 1 FADD: Fas-associated death domain TNF-: Tumour necrosis factor- TF: Transferrin FTH: Ferritin heavy chain FPN1: Ferritin 1 SLC7A11: Solute carrier family 7 member 11 4-HNE: 4-Hydroxynonenal PE: Phosphatidylethanolamine AdA: Arachidonic acid AdA-CoA: Adrenoyl-CoA LPCAT3: Recombinant lysophosphatidylcholine acyltransferase 3 LOX: Lipoxygenase RSL3: Methyl(1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]-indole-3-carboxylate PHD1: Hypoxia-inducible factor hydroxylase 1 LAMP2A: Lysosome-associated membrane protein type 2A HSPA5: Heat shock protein family A member 5 VDAC1: Voltage-dependent anion channel 1 NCOA4: Nuclear receptor coactivator 4 BCL-2: B-cell lymphoma-2 BAX: BCL-2-associated protein X NAIP: Neuronal apoptosis inhibitory protein NCCD: The Nomenclature Committee on Cell Death NLRP3: Nod-like receptor thermal protein domain-associated protein 3 CAMKII: Calcium/calmodulin-dependent protein kinase II RIPK3: Recombinant receptor-interacting serine threonine kinase 3 MLKL: Mixed lineage kinase domain-like MPTP: 1-Methyl-4-phenyl-1.2.3.6-tetrahydropyridine TFR: Transferrin DMT1: SLC11A2 FTL: Ferritin light chain GSSG: Glutathione SLC3A2: Solute carrier family 3 member 2 MDA: Malonaldehyde PUFAs: Polyunsaturated fatty acids AA-CoA: Arachidonic acid-CoA AA: Arachidonic acid ACSL4: Acyl-CoA synthetase long-chain family member 4 TPD52: Tumour protein D52 ARNTL1: Aryl hydrocarbon receptor nuclear transporter 1 CMA: Molecular chaperone-mediated autophagy HSPA8: Heat shock protein family A member 8 IFSP1: 1-Amino-3-(4-methylphenyl) pyrido [1,2-a] benzimidazole-2,4-dicarbonitrile USP7: Ubiquitin-specific protease 7 References Abdul Y, Li W, Ward R, et al

Epitalon works through several mechanisms

Statements Author contributions ZL: Conceptualization, Validation, Writing original draft

Given the pivotal role of energy metabolism in neuronal function and survival, current research is increasingly focused on uncovering the nuanced regulatory mechanisms governing these metabolic pathways