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However, in some cases, it progresses and causes complications, such as organ failure (mainly in the liver and kidney) [6], septic shock, pulmonary edema, severe pneumonia, and ARDS, which eventually may lead to death [7]

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The onset of metabolic inflexibility has been associated with micronutrient deficiencies and nutrient overload as well as the inevitable aging process

Dorostghoal, M., Kazeminejad, S., Shahbazian, N., Pourmehdi, M

Indeed, the PDH complex, which decarboxylates glycolytically derived pyruvate to acetyl coenzyme A and links cytoplasmic glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle, is modulated by reversible phosphorylation by PDH kinase (PDK)

A manual selection of the most relevant RCTs was made based on sample size, methodological/statistical rigor applied, and the types of exercise protocols specified in the main generally accepted guidelines