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The more NNMT activity, the more your NAD+ precursors get converted into a form your cells can't use

[DOI] [PubMed] [Google Scholar] 18.Ortancil O., Sanli A., Eryuskel R., Basaran A., Ankarali H.A

This drives increased appetite and slowed metabolism, making sustained weight loss difficult through diet alone

In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence