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polyphenols from white and green tea) Decrease of expression of genes related to oxidative stress and inflammation (e.g., hesperetin, rhaponticin, curcumin, taurine, atorvastatin) Increase of expression and activity on antioxidative enzymes and antioxidants (e.g., vitamin E, diallyl sulfide, hesperetin) Decrease of fatty acid synthase (FASN), and in consequence decrease of fatty acid level in the liver (resveratrol, DAS) Decrease of ROS level by binding of hydrogen ions and scavenging free radicals (e.g., polyphenols from white and green tea, curcumin, resveratrol) These compounds prevent cell/organism from oxidative stress provoked by BaP (conclusions 16) and reduce it through scavenging previously formed free radicals

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Cooper, N

Metabolite set enrichment analysis (MSEA) was conducted to identify pathways associated with the observed metabolite changes (Fig

A second protease of this family, proprotein convertase subtilisin/kexin type 6 (PACE4), also exists both intra- and extracellularly
