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In a study of 29 dogs with allergic dermatitis being treated with an antihistamine, those supplemented with 8.1 IU/kg of vitamin E daily (form not specified) showed a lower intensity of itching than dogs given a placebo, 44 supporting a possible role for this nutrient alongside conventional drug therapies

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Complementary clinical and meta-analytic data consistently demonstrate systemic redox imbalance, including lower glutathione reserves, altered GSH/GSSG ratios, increased lipid peroxidation, and dysregulated NRF2 signaling, linking oxidative status to immune activation and synaptic dysfunction (James et al., 2004

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