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Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

These beneficial properties have been attributed to their antioxidant, anti-microbial, and anti-inflammatory activities (Wen et al., 2020

This leads to clogged

73,74,75 Remarkably, the lysosomal cation channel MCOLN1 has been identified as a crucial mediator of zinc influx into the cytoplasm, thereby finely controlling oncogenic autophagy in cancerous cells

Factors contributing to the increased susceptibility of OLs to oxidative stress include the high intracellular iron content of the cells and relatively low levels of endogenous antioxidant proteins, which are lower in OPCs compared with mature OLs [14,15,23,24]

Since several ATGs and lysosomal cathepsin proteases depend on cysteines for their activities they can be the sensors or transducers of changes in the intracellular redox state through mechanisms involving redox signaling