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American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 1998

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Thus, increased renal ammoniagenesis and gluconeogenesis from plasma glutamine constitute an adaptative response that restores in part the acidbase balance during metabolic acidosis.[17] Renal catabolism of glutamine is acutely activated in response to the onset of metabolic acidosis and is primarily due to increased glutamine plasma and cellular decrease of glutamate and alfa-ketoglutarate (-KG)

10.1021/acsomega.9b02663 148 JinD.DaiK.XieZ.ChenJ

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