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Future research should adopt integrated, staged, and tissue-specific research strategies to systematically elucidate the precise modes of action of GPX4 and ferroptosis in different joint tissues and disease stages

Green tea extract contains compounds that can alter the metabolism of drugs processed by the liver

Metabolic reprogramming driven by oncogenes allows cancer cells to maintain deregulated cell proliferation, withstand metabolic challenges that are associated with diminished oxygen and nutrients, maintain a dedifferentiated state through alterations in global patterns of gene expression, and corrupt the surrounding microenvironment to actively facilitate tumor growth and dissemination 1618

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Photoluminescence (PL) spectra were recorded on a Perkin-Elmer LS 55 spectrofluorometer