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Inhibition of IGF-1R with figitumumab (anti-IGF-IR antibody) leads to downregulated receptor expression, inhibition of tumor growth [113], and radiosensitization of cancer cells [114]

Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) exhibited superior anti-cancer efficacy against breast cancer (MCF-7) cells by enhancing uptake, promoting early apoptosis via Bax/Bcl-2 pathway, and inhibiting tumor growth by over 60% in mice

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[DOI] [PubMed] [Google Scholar] 183.Bahlis N.J., McCafferty-Grad J., Jordan-McMurry I., Neil J., Reis I., Kharfan-Dabaja M., Eckman J., Goodman M., Fernandez H.F., Boise L.H., et al