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During the initial sensitization phase, cutaneous Langerhans cells capture the antigen and migrate to regional lymph nodes to generate memory T cells

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& Gubler, D

Once in the cytoplasm, intracellular thioesterases rapidly convert SAG to GSH

Beyond the glow, glutathione is a cornerstone for a strong immune system

However, if their degradation or biliary excretion are impaired, LPS can reach the systemic circulation, where they bind to Toll-like receptor 4 (TLR4) on leukocytes, endothelial cells, and platelets, causing arterial inflammation