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However, as an individual treatment and in combination with other antineoplastic medicines, curcumin has demonstrated promising effects in the treatment of several cancers: It has an impact on several signaling pathways and can therefore successfully alter both the initiation and progression of certain cancers (Zoi et al., 2021)

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Since RNAi is based on sequence homology, even short sequences of partial complementarity between the siRNA and a non-target transcript can result in unintentional silencing, potentially affecting non-target gene functions and resulting to undesirable phenotypic or ecological repercussions
Yoon et al., 2020