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Interestingly, all these pathways have been interlinked with the induction of profibrotic genes, epithelial-to-mesenchymal transition (EMT) or increased ECM deposition

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In contrast, diamide failed to increase the lifespan of pyg-1 -deficient animals, which accumulated the high level of glycogen (Fig

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doi: 10.1016/j.mce.2010.03.004