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Singh JA, Gaffo A (2020) Gout epidemiology and comorbidities

The aim is to provide new insights and evidence for further elucidating the role of selenium and selenoproteins in health maintenance, as well as for future nutritional guidelines and public health policies

Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

The methylcobalamin form in particular shows nerve-repairing properties, and has been shown to reduce homocysteine levels, treat peripheral neuropathy, ALS, multiple sclerosis, Alzheimer, Bells palsy, and other neurological disorders

Although targeting oxidative stress is theoretically logical, most strategies currently employed in the clinical setting have failed to improve patient prognosis
