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In murine models of ALI, bacterial pneumonia, and fungal pneumonia, the aerosol exhibited potent mucosal penetration and biofilm destruction capabilities, markedly reducing inflammation and pathogen loads while improving survival rates

These strategies can potentially aid experimental design, especially if in vivo phage display is used to discover homing peptides that can traffic to the brain (207)

and there are few interventions to restore the functional neuron circuitries (5, 6)

The scRNA-seq data have been deposited in the Gene Expression Omnibus database under accession code GSE283267

Given the role of CoQ 10 in bioenergetics and antioxidant activity, and the observation that CoQ 10 has protective effects against A-induced cell toxicity and impaired synaptic plasticity [134,162], CoQ 10 , and the processes regulated by it, have strong therapeutic potential in AD [163]