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The nuance is that a large share of autistic patients also show undermethylation traits, where aggressive folate therapy can occasionally activate irritability, anxiety, or sleep disruption

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Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

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10.1126/scitranslmed.3001387 [DOI] [PubMed] [Google Scholar] Culp M
