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Other studies have shown that changes in intestinal permeability occur before the onset of type 1 diabetes symptoms, and a change in TJ and dysbiosis associated specifically with a decrease in butyrate-producing bacteria have also been observed [1, 95]

In particular, the suboptimal pharmacokinetics and pharmacodynamics of these compounds and their poor ability to cross the BBB could represent considerable obstacles for a significant therapeutic efficacy

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Figure 1A shows that the mean ages are balanced across all three cohorts, and the proportion of females is roughly half among healthy controls and LC donors, with over 75% of ME/CFS donors being female

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