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Finally, we evaluated a mixture of indoxyl sulfate, phenyl sulfate, and p-cresyl sulfate at concentrations comparable to the serum concentrations of hemodialysis patients, and we confirmed its decreasing effect on glutathione level

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During this phase, two key regulatorsHIF-1 (the critical mediator of hypoxia response) and BMAL1 (the central component of the circadian rhythm)orchestrate the activities of bone-regenerating cells, ensuring proper cellular function and orderly progression of bone repair