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Gong XL, Jiang L, Li W, et al

Its commonly known that in addition to malignant tumor cells, TME contains various immune cells, such as lymphocytes and monocytes, as well as various stromal cells, such as fibroblasts and endotheliocytes, all of which have their own unique immunological or immunomodulatory capacity to determine whether a tumor will survive and form complex crosstalk with nearby cells ( In fact, novel immunotherapeutic strategies targeting TME, including immune checkpoint blockade have been clinically applied in antitumor therapy ( Recently, the anti-cancer and immunomodulatory effects of many natural compounds have attracted increasing attention

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[PubMed] [Google Scholar] 62.Landmesser U, Dikalov S, Price SR, et al

Animal studies point to a role for glutathione in mitigating neuronal oxidative stress.[ref] There are glutathione supplements available, or N-acetylcysteine (NAC) supplements may also increase glutathione levels by providing the cysteine needed for the synthesis of glutathione.[ref] PEA (phenylethylamine): PEA is a substrate of MAO-B in specific brain regions

Islets from patients with T2D have increased lipid peroxidation adducts (MacDonald et al., 2013) and these lipid peroxides impair mitochondrial function by damaging mtDNA, RNA, and ETC machinery (Lang et al., 2011