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Regardless of these factors, it seems like treating AA in earlier stages leads to better outcomes and decreases the risk of future treatment resistance

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10.1158/1078-0432.CCR-06-1480 198 WuJ.ZhaiT.SunJ.YuQ.FengY.LiR.et al (2022)

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Topical glutathione is best for brightening and color correction in specific areas of the face