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doi: 187

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Clinical significance of colonic fermentation

The oxidative damages of biomolecules specifically of DNA due to the accumulation of hydroperoxides and other ROS ultimately lead to the loss of cell viability or cell death through various death mechanisms like apoptosis, autophagy, necrosis, ferroptosis, and mitotic catastrophe (Fig

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S2), clearly demonstrating that uncatalyzed glutathionylation of regular protein thiols occurs much too slowly at low physiological GSSG concentrations to compete with glutaredoxin-dependent glutathionylation 63