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demonstrated in 1999 that topical or intraperitoneal administration increased re-epithelialization by 42 percent over saline controls at day 4 and by 61 percent at day 7 in a rat wound model.18 Allan Goldstein at George Washington University, who pioneered the isolation of thymosins, described thymosin beta-4 as a multi-functional regenerative peptide with applications from cardiac repair to corneal healing.19 Relevance to Endurance Athletes The endurance rationale for TB-500 centers on three effects: angiogenesis promotion (new blood vessel formation improving tissue perfusion), inflammation modulation (calming excessive responses that delay recovery), and anti-fibrotic activity (reducing scar tissue that causes stiffness and re-injury risk).20 In preclinical models, accelerated healing of connective tissue and improved muscle recovery after endurance exercise have been reported

Some conditions to test for or be concerned about are thyroid issues, pre-existing heart conditions, or high blood pressure

This means: Do not reconstitute in any buffer containing DTT, BME, or glutathione

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doi: 10.1016/j.ijbiomac.2020.06.153 223 WojcikowskiKJohnsonDWGobG

Polymeric delivery systems for nucleic acid therapeutics: approaching the clinic