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This section provides a detailed analysis of these critical determinants, synthesizing current evidence to elucidate their individual and synergistic roles in initiating, amplifying, and perpetuating the transition from acute nociception to persistent chronic pain

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However, these findings may not be directly applicable to humans[226]

Nevertheless, there are some countries and regions in the Pacific, namely Tonga, Fiji, and Pohnpei, where kava ceremonies are practiced as a vital part of local culture [7]

doi: 10.1167/iovs.63.12.18 94 ZhangZJingJYeYChenZJingYLiSet al

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