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This distinction proved relevant in animal studies where PT-141 produced: Penile erections in rats and non-human primates following systemic administration Erections after direct injection into brain ventricles, confirming central site of action Effects that persisted even when peripheral vascular function was compromised Enhanced sexual motivation behaviors distinct from purely erectile responses Preclinical Animal Studies Sexual Behavior in Female Rodents Landmark research using female rats in pacing chambers demonstrated PT-141s selective effects on appetitive sexual behaviors

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Occasionally allergic reactions have been reported, mostly manifesting as pain and/or rash at the injection site

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Representative blots of at least two independent experiments are shown

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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.James S., Stevenson S.W., Silove N., Williams K

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Glutathione Dysregulation and the Etiology and Progression of Human Diseases

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The association between OS and RM was also supported by other studies (198, 201, 202)

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