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3.1.2 Ca 2+ overload in cardiomyocytes Ca 2+ is a key regulatory ion in cardiac excitation-contraction coupling

ASS1 expression is downregulated in CHOL, GBM, KICH, KIRC, KIRP, and LIHC tumor categories, suggesting the feasibility of arginine depletion therapy

Mutation spectrum of copper-induced DNA damage

Indeed, GSH can influence cell death pathway by modulating the level of mitochondrial ROS, as has been demonstrated in the case of tumor necrosis factor (TNF) (Garcia-Ruiz and Fernndez-Checa, 2007)

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Importantly, IGF1R expression also determine RCC aggressiveness, while patients with clear-cell RCC shown kidney IGF1R expression higher than 50% have shorter survival time, a difference that becomes particularly significant after two years of follow-up.40 Moreover, after adjustment for age and stage at diagnosis, those patients with renal IGF1R expression higher than 50% had a 4.2 increased risk of death compared to those with lower renal IGF1R expression