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This group includes liberated Hb and an enzyme called arginase 1 8

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Excessive antibiotic use can disrupt gut flora, promoting dysbiosis and increasing vulnerability to inflammation, while smoking paradoxically appears to reduce UC risk and offers some protection, although it must be mentioned that smoking carries major prohibitive systemic health risks, despite the fact that nicotine may present anti-inflammatory effects [6,7]

Oral administration is typically preferred for gut-specific goals, though injectable can address both gut and systemic inflammation simultaneously