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The neutrophil-derived chemokines also lead to the recruitment of other types of immune cells, such as monocytes, macrophages and dendritic cells [65]

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Given that portal delivery of insulin, which has the potential to completely restore IGF-I levels in type 1 diabetes (70, 71, 87), remains an experimental treatment, rhIGF-1 treatment to restore circulating IGF-I and suppress GH and decrease insulin needs appears to be the most feasible approach to take (88)