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Ectopic endometrial tissue in patients with endometriosis often displays a proliferative phenotype reminiscent of cancer cells, characterized by unchecked growth, local invasion, angiogenesis, distant metastasis and the presence of multiple lesions (61)

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This shifts metabolite profiles toward immunosuppressive bile acids (TCA) and reduced IPA, promoting MDSC accumulation and impairing hepatic immunosurveillance in non-alcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) (243, 310)

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Experimental Section 4.1

M., Goldberg, R