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Relationships between inflammation, hemodynamic function and RAAS in longstanding type 1 diabetes and diabetic kidney disease

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Studies in mice also indicated that oxidative stress induced by selenium deficiency could result in changes in the viral genome, such as to convert a relatively harmless strain of coxsackie virus B3 into a myocarditis-causing strain (56)

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Curr Protoc Chem Biol 9(3):196212

Thus, it should be inferred that deterioration and inefficiency of these key methyl group metabolic pathways may contribute to DNA methylation aberrations as we observed in dedifferentiation processes, aging, and cancer initiation and justifiably assume their causal role