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Figure 4 3.2 Dysregulation of inflammatory cytokinesthe core of excessive immune inflammatory responses Acute dysregulation of MPP typically occurs during the early phase of infection (12 weeks), characterized by excessive or dysregulated activation of the host innate immune system: (i) At the immune level, this primarily involves excessive cytokine release alongside overactivation of innate immune cells, initiating multifaceted proinflammatory cascades including NLRP

Oligodendrocytes are particularly vulnerable to cuprizone-induced mitochondrial dysfunction 7 , resulting in apoptosis 1 and subsequent loss of myelin 4

Many patients also report feeling more energetic and emotionally balanced

Papaya Papain in papaya improves your digestion and prevents fat accumulation in liver

The vegetable also has anti-inflammatory and antibacterial properties

Supplementary Data 8 (download XLSX Numerical source data for Supplementary Fig
