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In addition to the direct action of the omega-3 fatty acids EPA and DHA, and also to some extent DPA, there are numerous metabolites of these fatty acids that are classified as bioactive lipids

TMAO can aggravate acute electrical remodeling in AF models and enhance atrial electrophysiological instability in normal canines by enhancing autonomic remodeling and boosting the p65 NF-B signaling pathway [84]

Progressive cardiac dysautonomia observed in patients affected by classic Rett syndrome and not in the preserved speech variant

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Levels of the antioxidants SOD and GSH-Px were decreased in group B, suggesting that antioxidant activity was increased and antioxidant enzyme consumption was increased