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Any wheal and flare reaction were not induced by saline (negative control)

Similar to NNMT overexpression, MNA-treated hepatocytes show a dose-dependent increase in glucose production, Sirt1 protein expression, G6pc mRNA expression, and Pck1 mRNA expression compared to controls and these changes caused by MNA treatment can be abolished by Sirt1 knockdown [14]

Cycle Length and Continuous Use Clinical trials have safely used AOD-9604 for durations ranging from single doses to 24 weeks of continuous daily administration
