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Conditions for which this effect has been demonstrated are: glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency.7,8 Autointoxication occurs in these patients due to the accumulations of acylCoA compounds that disrupt intermediary metabolism

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10.1016/j.biocontrol.2011.11.002 103 MaleckK.LevineA.EulgemT.MorganA.SchmidJ.LawtonK
