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Erastin, as a small-molecule ferroptosis inducer, works by inhibiting the system Xc transporter-an amino acid antiporter responsible for exchanging extracellular cystine for intracellular glutamate (11)-leading to depletion of intracellular glutathione (GSH), indirectly inactivating glutathione peroxidase 4 (GPX4), and ultimately triggering ferroptosis (12)

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Frequently Asked Questions Why is it medically recommended to cook mushrooms rather than eating them raw

Experimental Use Notice: Peptide supplementation is considered experimental and may not be appropriate

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PMID: 13 DumontMPaquetJ