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This quenched method further enabled the quantification of other interesting metabolites in the Cys pathway, such as cysteine, -Glu-Cys and Cys-Gly, which were all markedly increased in the SSC condition (Figure 2E)

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Enforced PGC-1alpha expression promotes CD8 t cell fitness, memory formation and antitumor immunity

Aside from such examples of myelin/OLG relevant genes identified through GWAS, transcriptomic analyses reveal gene expression changes in additional myelin-related genes in a broad range of neurodegenerative diseases, including AD [3], PSP [3], MSA [82], and frontotemporal lobar degeneration (FTLD) [39], further supporting the idea of myelination changes as a common pathway across these diseases