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Despite the clear connection between UPR mt activation and longevity in the context of mitochondrial translation inhibition, UPR mt activation is also observed in short-lived mitochondrial mutants, and constitutively active alleles of ATFS-1 exhibit reduced lifespan 15

[19] [21] The duration of therapy depends on the indication and patient response

Taking more than the advanced dose rarely leads to faster or better results and significantly increases the risk of side effects (e.g., water retention, numbness, nausea)

aureus 20

Thereby, knockdown of Grx1 leads to increased levels of SLC7A11 and of GSH in lung cells [129]

Glutathione and NAC