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10.1038/s41420-024-02278-8 40 CheD.XiaoY.ZhangX.ZhuK.ChenW.YouG.et al (2025)

179 Additionally, aspirin has been found to inhibit platelet-induced upregulation of the oncoprotein c-MYC, effectively interrupting the pro-tumorigenic signaling in SW480 and PANC-1 cell lines

However, this effect may be due to the large amount of cystine provided in the control conditions (208 M), as reduction of cystine levels in the medium did not impair growth but abolished intracellular cysteine and cystine levels (Extended Data Fig

Radzinski M., Oppenheim T., Metanis N., and Reichmann D., The Cys Sense: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins, Biomolecules 11, no

Further purification of this 55 kDa band was accomplished by ion-exchange column chromatography using DEAE-sepharose with a 150-450 mM NaCl gradient