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Xydakis AM, Case CC, Jones PH

Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients

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Research in animal models suggests that Epitalon may help restore disrupted hormonal signaling and support the bodys natural timing systems, particularly through its effects on the pineal gland and melatonin secretion

IV formulations can be effective, however the costs can be significant ($900 per session), factor in 4 sessions, for temporary results that typically last 3-8 weeks
