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This is especially important for individuals with absorption issues, such as those with gut inflammation or certain dietary restrictions

We think that the [neurons influence] on intervertebral disc degeneration is not only limited to the occurrence of pain, but also intervertebral disc degeneration itself, said Ximing Xu, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study

However, this popularity has often outpaced the actual clinical evidence, creating a significant gap between laboratory enthusiasm and evidence-based claims about human application

Most available research comes from animal and laboratory studies

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A confidence interval needs to be computed for each parameter estimate because this allows to obtain a range for the parameter estimate, which gives an indication about the uncertainty of the parameter value taking into account the quantity and variability of the data