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Clinical implications and the migraine connection An important clinical consideration has emerged from the migraine treatment field

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In particular, activation of the hypothalamo-pituitary-adrenal (HPA) axis by stress results in the somatostatin-mediated inhibition of thyroid-releasing hormone (TRH) and thyroid-stimulating hormone (TSH) release and in reduced conversion of thyroid T4 to T3 (active hormone) that in humans, displays a negative control on various CYP genes including those belonging to the CYP3A subfamily (50)

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