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82 The promising mechanism of action of TLK286 and its positive preclinical data have sparked a series of clinical trials where the prodrugs have been applied alone or in combination with other standard chemotherapeutic agents

developed a ketoprofen-loaded islet encapsulated system to prevent early loss (70)

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This also raises an unresolved question as to whether GSH efflux serves primarily as a permissive biochemical event or represents an actively regulated signaling step in apoptotic commitment

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