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Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

doi: 10.1016/j.cell.2022.12.027
Ahmad R, Riaz M, Khan A, Aljamea A, Algheryafi M, Sewaket D, Alqathama A (2021) Ganoderma lucidum (Reishi) an edible mushroom

| 2024 Edition TB-500 is available online and may be purchased by researchers for experimentation

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The practical difference is consistency