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347 This was achieved by decreasing the expression of proinflammatory cytokines such as tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8)

Unlike larger therapeutic proteins, peptides are smaller and often break down faster in the digestive system, which is why many are administered through Peptide injections

to mice

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In spite of more resistant biochemical properties of D-form against proteases and peptidases, L-penetratin showed better efficiency than D-penetratin in nasal insulin delivery

[DOI] [PMC free article] [PubMed] [Google Scholar] Wallert M, Ziegler M, Wang X, Maluenda A, Xu X, Yap ML, Witt R, Giles C, Kluge S, Hortmann M, Zhang J, Meikle P, Lorkowski S, Peter K