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One of the striking phenotypes of SOD1-deficient mice is female infertility and this is discussed below

Part of it is secondary to oxidative stress, which is well documented to occur during endotoxemia (Zhang et al., 2000)

10.1002/glia.23480 Glia 82 LiuQ

Cancer Epidemiol Biomarkers Prev 19(6):1484-91, 2010

Transplantation 103 , 420427 (2019)

The loss of topoisomerase II or its inhibition by fluoroquinolones results in accumulation of positively supercoiled mtDNA, followed by cessation of mitochondrial transcription and replication initiation, causing depletion of mtDNA copy number
