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Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer

The administration of glutathione resulted in enhanced levels of antioxidant biomarkers among individuals diagnosed with COPD, accompanied by a minor and statistically insignificant decrease in the levels of the anti-inflammatory mediators IL-8 and TNF-alpha

Targeted approaches, including antioxidant therapy, lifestyle modification, and sperm selection techniques (e.g., microfluidic sorting, magnetic-activated cell sorting), aim to mitigate DNA damage ( 4.4 ROS-mediated epigenetic modifications: DNA methylation, histone retention, and sperm RNAs Beyond structural DNA damage, OS profoundly influences the sperm epigenome, affecting not only fertility but also transgenerational health (108)

It is associated with impaired testosterone secretion, which may result from primary organ failure or is associated with the disruption of the secretion of pituitary hormones

These metabolites include lipid peroxidation end products (malondialdehyde, F2-isoprostane, HNE, acrolein and Ox-LDL), oxidized proteins (protein carbonyl and protein nitrotyrosine), DNA oxidation (8-OHdG), nitric oxide and antioxidant enzymes (SOD, CAT, GPx, GR and total antioxidant capacity [17, 44, 45]

and Ministry of Science and Innovation (PID2019-107548RB-I00)