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Treatment with a ferroptosis inhibitor was found to reverse these effects, proving that Nrf2 deletion induces ferroptosis in spermatogenic cells, thereby contributing to oligospermia pathogenesis

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Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

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TLK199, one such lead compound, is a peptidomimetic glutathione analogue that is a low micromolar inhibitor of GST (Figure 2) (Lyttle et al ., 1994a,b)

ROS-associated tumor immunity in cellular immunotherapy In the field of cellular immunotherapy, especially with therapies represented by CAR-T and CAR-NK cells, the redox state of the TME is a key obstacle determining their efficacy