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Therefore, curcumin has the potential to modulate IBDs through several mechanisms described in preclinical models

doi: 10.1080/19490976.2022.2102878

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published in Molecular Brain confirmed endogenous MGF expression in neurogenic brain areas with age-dependent decline, and that transgenic MGF overexpression significantly increased BrdU+ proliferative cell counts in the dentate gyrus and subventricular zone of the hippocampus establishing MGF as a neurogenesis-promoting factor in ageing brain biology and directly relevant to PEG-MGF neurogenesis and neuroprotection research applications

The study quantified oxidative and nitrosative stress markers, mitochondrial respiratory chain complex activities, and inflammatory mediators such as TNF- and MMP-9, using spectrophotometric assays and ELISA

The functioning of the pituitary gland and the hormones it secretes decreases with aging, however, IGF-1 is capable of bypassing the pituitary gland and is able to elicit the same response as GH does