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Another drug repurposed is metformin (clinically used as an anti-diabetic) which is being used as an AMPK activator, currently in phase II clinical trials for CLL (ClinicalTrials.gov: NCT01750567) (105, 106)

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Randomized double-blind trial of combined modality treatment with or without amifostine in unresectable stage III non-small-cell lung cancer

As indicated above kynureninase, which is encoded by the KNYU gene, is also used for the conversion of kynurenine to anthranilic acid with the release of alanine

Antioxidants, 8 (9)

Melatonin prevents metal oxidation by neutralizing free radicals produced in redox reactions, such as the Fenton reaction and the HaberWeiss reaction (HWR), or by chelating metal ions [70]