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She began with 10 patients

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(14) Just this month, June 2016, a meta-analysis of 11 prospective studies, including 29,155 participants, found significant inverse association between highest coffee consumption and the risk for Alzheimers disease a 27% reduction in risk

Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, et al

Even after adjusting for age, sex and habit the AA-genotype is found to be significantly associated with oral cancer (OR = 2.4, 95% CI = 1.73.2, p = 0.0001)