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Some only experience occasional hot flashes while, for others, the symptoms can get in the way of daily life

Additionally, metformin significantly reduces macrophage-induced ROS accumulation and senescence in primary GCs by inducing the expression of the AMPK pathway and protects against CTX-induced POF (Yang et al., 2024)

Studies showed that SIRT1 prevents H 2 O 2 -induced oxidative stress and apoptosis by mediating autophagy in trophoblasts [39]

Blood flow and hypoxia

Glutathione activates the Nrf2/HO-1 signaling pathway, a critical transcriptional regulator of antioxidant gene expression

Hepatology Communications 3(5):656669 Zhou Z, Ye TJ, DeCaro E, Buehler B, Stahl Z, Bonavita G, Daniels M et al (2020) Intestinal SIRT1 deficiency protects mice from ethanol-induced liver injury by mitigating ferroptosis